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Featured Online Highlight Clinical Decisions Preexposure Prophylaxis for HIV Prevention S.S. Abdool Karim, G.E. Gray, and N. Martinson Two patients — a 46-year-old man from New York who has sex with men and an 18-year-old heterosexual woman with multiple partners in South Africa — are at risk for infection with HIV. Would you recommend initiating preexposure prophylaxis? Vote and comment at NEJM.org. This Week at NEJM.org | August 2, 2012 Listen to the Weekly Audio Summary Perspective Patient Access to Medical Devices — A Comparison of U.S. and European Review Processes S. Basu and J.C. Hassenplug | August 1, 2012 | DOI: 10.1056/NEJMp1204170 Are Americans Ready to Solve the Weight of the Nation? C.L. Barry, S.E. Gollust, and J. Niederdeppe | N Engl J Med 2012;367:389-391 The Growing Role of Emergency Departments in Hospital Admissions J.D. Schuur and A.K. Venkatesh | N Engl J Med 2012;367:391-393 | Published Online July 11, 2012 Medicare and Medicaid Spending Trends and the Deficit Debate J. Holahan and S. McMorrow | N Engl J Med 2012;367:393-395 Overbilling and Informed Financial Consent — A Contractual Solution B.D. Richman, M.A. Hall, and K.A. Schulman | N Engl J Med 2012;367:396-397 Original Articles Antiretroviral Prophylaxis for HIV Prevention in Heterosexual Men and Women J.M. Baeten and Others | N Engl J Med 2012;367:399-410 | Published Online July 11, 2012 Preexposure Prophylaxis for HIV Infection among African Women L. Van Damme and Others | N Engl J Med 2012;367:411-422 | Published Online July 11, 2012 Antiretroviral Preexposure Prophylaxis for Heterosexual HIV Transmission in Botswana M.C. Thigpen and Others | N Engl J Med 2012;367:423-434 | Published Online July 11, 2012 Combination Anastrozole and Fulvestrant in Metastatic Breast Cancer R.S. Mehta and Others | N Engl J Med 2012;367:435-444 Review Article 200th Anniversary Article: Doctors, Patients, and Lawyers — Two Centuries of Health Law G.J. Annas | N Engl J Med 2012;367:445-450 Images in Clinical Medicine Unexpected Swallowing of a Knife A. Venado and S. Prebil | N Engl J Med 2012;367:451-451 Hernia through the Foramen of Winslow W.C. Huang and C.-Y. Fu | N Engl J Med 2012;367:e7 Clinical Problem-Solving Breathtaking Journey D.K. Rhee and Others | N Engl J Med 2012;367:452-457 Editorial Preexposure Prophylaxis for HIV — Where Do We Go from Here? M.S. Cohen and L.R. Baden | N Engl J Med 2012;367:459-461 | Published Online July 11, 2012 Clinical Decisions Preexposure Prophylaxis for HIV Prevention S.S. Abdool Karim, G.E. Gray, and N. Martinson | N Engl J Med 2012;367:462-465 | Published Online July 11, 2012 Sounding Board Election 2012: A Systemic Approach to Containing Health Care Spending E. Emanuel and Others | August 1, 2012 | DOI: 10.1056/NEJMsb1205901 Election 2012: Bending the Cost Curve through Market-Based Incentives J.R. Antos, M.V. Pauly, and G.R. Wilensky | August 1, 2012 | DOI: 10.1056/NEJMsb1207996 Health Policy Report Care Redesign — A Path Forward for Providers T.H. Lee | N Engl J Med 2012;367:466-472 | Published Online July 29, 2012 Correspondence Bariatric Surgery or Medical Therapy for Obesity Comparative Effectiveness of Revascularization Strategies Low-Dose Abdominal CT for Diagnosing Appendicitis Association of a HOXB13 Variant with Breast Cancer Corrections Hydr Two Hundred Years of Surgery A Pooled Analysis of Vitamin D Dose Requirements for Fracture Prevention oxyethyl Starch 130/0.4 versus Ringer’s Acetate in Severe Sepsis Pencil-Core Granuloma Image Challenge What is the diagnosis? Submit Answer » Browse All Online First Articles » Trends: Most Viewed (Last Week) A Reader's Guide to 200 Years of the New England Journal of Medicine January 5, 2012 Coronary CT Angiography versus Standard Evaluation in Acute Chest Pain July 26, 2012 Mortality and Access to Care among Adults after State Medicaid Expansions July 25, 2012 More Trends Subscribe to NEJM, Now Includes NEJM iPad Edition & Bonus Gifts NEJM is celebrating its 200th anniversary! Subscribe today and get subscriber-only access to NEJM.org and the NEJM iPad Edition. Your subscription includes 20 FREE online CME exams (earn up to 20 CME Credits) and 50 FREE article views from the NEJM Archive 1812–1989, PLUS your anniversary gift of 200 additional free CME exams and 200 bonus archive views. Subscribe Today! DIRECTOR — PENNSYLVANIA Director of Research, Geisinger-Northeast. Geisinger Health System is seeking a Director of Research, Geisinger-Northeast (GNE), for the northeastern Pennsylvania region of the health system. Geisinger is a physician-led system dedicated to healthcare, education, research, and service. The Director of Research, GNE will be responsible, in conjunction with GNE leadership and the Chief Scientific Officer, for overseeing all research conducted in the Northeast and for supervising core resources. About the Position: The Director of Research, GNE is responsible for the design and development of a major expansion of the research programs in the Northeast in keeping with the Research Strategic Plan.... Looking for a new practice opportunity? View this job and other listings at NEJM CareerCenter. Search now for both permanent and locum tenens jobs in many specialties. Follow us