NEJM

NEJM 200th Anniversary Documentary Getting Better is a 45-minute documentary video that tells three remarkable stories of medical progress — surgery, leukemia, and HIV/AIDS. Atul Gawande, Vincent DeVita, Tony Fauci, Paul Farmer, and other prominent experts explore research, clinical practice, and patient care, and how health care has continued to get better over the past 200 years. View the film in its entirety, or in segments, now on the 200th anniversary website. This Week at NEJM.org | August 9, 2012 Listen to the Weekly Audio Summary Perspective When the Cost Curve Bent — Pre-Recession Moderation in Health Care Spending C. Roehrig and Others | August 8, 2012 | DOI: 10.1056/NEJMp1205958 Patient Access to Medical Devices — A Comparison of U.S. and European Review Processes S. Basu and J.C. Hassenplug | N Engl J Med 2012;367:485-488 | Published Online August 1, 2012 The Ethics of Early Evidence — Preparing for a Possible Breakthrough in Alzheimer’s Disease J. Lowenthal, S.C. Hull, and S.D. Pearson | N Engl J Med 2012;367:488-490 Use Patents, Carve-Outs, and Incentives — A New Battle in the Drug-Patent Wars A. Rai | N Engl J Med 2012;367:491-493 Original Articles Placebo-Controlled Trial of Tofacitinib Monotherapy in Rheumatoid Arthritis R. Fleischmann and Others | N Engl J Med 2012;367:495-507 Tofacitinib or Adalimumab versus Placebo in Rheumatoid Arthritis R.F. van Vollenhoven and Others | N Engl J Med 2012;367:508-519 Treatment of Older Patients with Mantle-Cell Lymphoma H.C. Kluin-Nelemans and Others | N Engl J Med 2012;367:520-531 Prospective Trial of a Pediatric Ventricular Assist Device C.D. Fraser Jr. and Others | N Engl J Med 2012;367:532-541 Clinical Practice Diagnosis of Diabetes S.E. Inzucchi | N Engl J Med 2012;367:542-550 Images in Clinical Medicine Halitosis and Sensory Loss C. Scully and A.E. Brooke | N Engl J Med 2012;367:551-551 Green Teeth in Neonatal Sepsis O. Swann and A. Powls | N Engl J Med 2012;367:e8 Case Records of the Massachusetts General Hospital Case 24-2012: A 38-Year-Old Man with Abdominal Pain and Altered Mental Status A.T. Fathi, Y.-B. Chen, B.W. Carter, and R.J.H. Ryan | N Engl J Med 2012;367:552-563 Editorials Kinase Inhibition — A New Approach to the Treatment of Rheumatoid Arthritis D.A. Fox | N Engl J Med 2012;367:565-567 Pediatric Ventricular Assist Devices — First Steps for Babies L.J. Addonizio | N Engl J Med 2012;367:567-568 Reviewers for the Journal, January–June 2012 N Engl J Med 2012;367:569-569 Transparency for Clinical Trials — The TEST Act J.M. Drazen | August 8, 2012 | DOI: 10.1056/NEJMe1209433 Clinical Implications of Basic Research Preclinical Success against Alzheimer’s Disease with an Old Drug F.M. LaFerla | N Engl J Med 2012;367:570-572 Correspondence Lenalidomide for Multiple Myeloma Coffee Drinking and Mortality Off-Pump or On-Pump Coronary-Artery Bypass Grafting Whistling in the Dark More on Chronic Cyclic Non-Nephrogenic Magnesium Depletion without Losses Prevalence and Monitoring of Oligosecretory Myeloma Corrections Radical Prostatectomy versus Observation for Localized Prostate Cancer Two Hundred Years of Surgery Bisphosphonate Use and Atypical Fractures of the Femoral Shaft