Dear Reader,
This update brings you several unique ways to engage with the information you trust from NEJM. View videos, test your diagnostic skills with an interactive case, explore NEJM on your iPad, and vote on the latest Clinical Decisions. Read on to learn more.
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 What are the challenges in developing an HIV vaccine? What strategies do we need to solve maternal/fetal health issues today? How can breast cancer patients be diagnosed and treated more effectively? How can we insure that advances in cardiology make the patient's life better? Prominent experts gathered in Boston on June 22 to discuss these questions and many more in a stimulating and inspiring day-long symposium. It is now available for you to watch, in segments, or in its entirety. Four panel discussions - on HIV/AIDS, maternal and fetal health, breast cancer and cardiology - explore how medical research and practice have evolved to improve people's lives over the past two centuries. See heroic patients Robert Massie, Robin Roberts and Desmond Jordan, and experts in their fields Paul Farmer, Tony Fauci, Margaret Hostetter, Nawal Nour, Marc Lippman, Joe Loscalzo, Eugene Braunwald, and others talk about the past, present and future of medicine. View the videos on the 200th anniversary site now.
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In a new study from Heijnsdijk and colleagues, PSA screening of men aged 55-69 years produced a 28% reduction in deaths due to prostate cancer. However, 98 men needed to be screened and 5 cancers needed to be detected to save a single prostate cancer death. The quality-adjusted life years gained through screening is reduced by 23% when overdiagnosis and treatment sequelae are considered. Will this change the way you approach the topic of prostate cancer screening? Read the article, the editorial from Dr. Harold Sox, which says this research "shows the way to a resolution of the long-standing controversy about screening for prostate cancer," and comment now! Also, see our latest Clinical Decisions on this topic. Read a case vignette and the arguments for and against recommending PSA screening and cast your vote!
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 The new NEJM iPad Edition offers a unique and enhanced reading experience each week. With the app, you can easily navigate to the articles that interest you most in each issue, pinch/zoom images, tables and figures for closer viewing and watch Videos in Clinical Medicine and other videos. You can read each week's CME exams and link to the exams online. And you can read Online First articles as soon as they're published, before they appear in print. Best of all, you can take all of your downloaded issues with you wherever you (and your iPad) go.
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Legal procedures and courtrooms have changed little, but there have been almost as many changes in the application of law to medicine over the past 200 years as there have been changes in the practice of medicine. A new review article from Boston University's George Annas discusses the evolution of health law since 1812, and references Herman Melville's 1851 masterpiece, Moby-Dick, as symbolizing the view of many physicians, then and now, that medical malpractice litigation is the white whale: evil, ubiquitous, and seemingly immortal. See previous reviews on neurology and psychiatry, cancer research, surgery, pediatrics, asthma, infectious disease, and coronary artery disease. On September 6th, look for Paul Farmer's review on tuberculosis.
In a new Perspective this week, University of North Carolina's Jonathan Oberlander looks back at a century of health care reform in the United States. Other recent Perspectives in this series include Jerry Avorn on the history of drug safety and efficacy, and an article from three Harvard historians on the burden of disease and the changing task of medicine.
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 In a new Interactive Medical Case, "Disconnected," a 58-year-old white woman presented to the emergency department with palpitations and lightheadedness. While taking a shower that morning, she had sudden onset of lightheadedness, pain in the front of her chest when taking deep breaths, and mild shortness of breath. What diagnostic and management steps do you choose? Receive feedback on your choices and learn more about her condition and optimal treatment steps when you explore this case now at NEJM.org.
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We hope you found something you like. As always, we welcome your feedback.
Sincerely,
Thomas J. Easley
Publisher
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Your subscription now includes access to the NEJM iPad Edition!
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*This one-time benefit is available to all paid subscribers and must be used by 12/31/2012
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A 12-year-old boy was admitted to the hospital because of fever, chills, sweats, productive cough, nausea, and vomiting. The patient had a history of recurrent pneumonias since age 5. What's the diagnosis?
Looking for more medical images?
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The physician-editors of Journal Watch have created a new collection of the Ten Most-Read Summaries in Clinical Research of the past 6 months, conveniently organized into a single PDF. This collection is essential reading for all clinicians! FREE for a limited time exclusively on JWatch.org. Download your
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