Ronaldo's hat-trick meant he became the first player to reach 50 goals in the Champions League knockout stages. He has 52 in total.
The Portuguese is the only man to score 100 goals in European competition.
He has now scored 13 semi-final goals in the Champions League (10 for Real Madrid, three for Manchester United) - the most by any player, including when the tournament was called the European Cup.
The 32-year-old has scored two consecutive Champions League hat-tricks, and eight goals in his past three games in the tournament.
That’s now 399 goals for Real Madrid alone. He joined them in 2009.
Ronaldo is the only player in world football to have scored in the 2006, 2010 and 2014 World Cup and the 2004, 2008, 2012 and 2016 European Championships.
He is the top scorer in the entire history of Europe's top six leagues with 367 goals and counting.
For clubs (Sporting Lisbon, Manchester United and Real Madrid) and country his record now stands at 852 games and 593 goals.
Cristiano Ronaldo dos Santos Aveiro is not an easy man to warm to. He is selfish, can act childish, is perhaps the vainest person to ever strut the earth and you just know he would not be the greatest company down the pub.
However, he is an incredible footballer, easily in the top five of all time, with his latest heroics coming at a time when some of the Madrid supporters, and the Spanish media as well, started to think he was slowing down. Ronaldo on an average day is the equivalent 95 per cent of others players when name man of the match.Ronaldo is addicted to scoring goals and winning games. He is rarely injured, treats the smallest matches as if they were European Cup Finals and for such a prima donna he goes in where it hurts to score his goals.
"For me all games are important, it depends how you want to interpret them," Ronaldo told UEFA.com. “I always look at them in a serious manner because I want to win and goals allow us to relax and have an advantage.
"It's an advantage and I won't lie – a good, very good one. But we can't take anything for granted. We have to go into the return leg at the Calderón fully focused. We know football is a box of surprises and for that we need to be wary. We know it will be a difficult game but we've got a good advantage. We need to be wary and go there and play a good game, too."
After captaining Portugal to the European Championships last summer, weeks after winning a third Champions League, he is a few matches away from bring a four-time winner in Europe and also taking the La Liga title from Barcelona. It has been some 12 months even by is standards.
Phil Neville, the former Manchester United player, compared the Portuguese gave an insight into what makes Ronaldo tick.
He said: “Cristiano has natural ability coupled with hard work. He is a tremendous example of where hard work can take you. When we were at Manchester United he said he wanted to go on to be the best player in the world. He had the self-belief to get to the very top.“United's Carrington training ground is maybe a mile, two miles around. Every single day he used to take a ball after training and run and do his tricks for a mile, two miles at a time. His drive and his ability to practise every single day is just phenomenal.”
When someone is this good they can be as vain as they want.
