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NEJM iPad Edition: Now with Highlighting, PDFs, and More The NEJM iPad Edition now has more options for you to view and manage content, including the ability to highlight text, export PDFs and PowerPoint slides, and view images optimized for Retina display. This week's issue is always available Explore the enhanced NEJM iPad Edition today >> This Week at NEJM.org | November 15, 2012 Listen to the Weekly Audio Summary Perspective Seeing in the Dark E. Manheimer | November 14, 2012 | DOI: 10.1056/NEJMp1213611 The Storm and the Aftermath D. Ofri | November 14, 2012 | DOI: 10.1056/NEJMp1213843 Facing Uncertainty — Dispatch from Beth Israel Medical Center, Manhattan S. Jangi | November 14, 2012 | DOI: 10.1056/NEJMp1213844 Repackaging Cigarettes — Will the Courts Thwart the FDA? R. Bayer, L. Gostin, and D. Marcus-Toll | November 14, 2012 | DOI: 10.1056/NEJMp1211522 Lessons Learned Preparing for Medicare Bundled Payments R. Mechanic and C. Tompkins | N Engl J Med 2012;367:1873-1875 Reducing Administrative Costs and Improving the Health Care System D. Cutler, E. Wikler, and P. Basch | N Engl J Med 2012;367:1875-1878 The Reciprocity of Recognition — What Medicine Exposes about Self and Other R. Charon | N Engl J Med 2012;367:1878-1881 Original Articles Differentiation of Reinfection from Relapse in Recurrent Lyme Disease R.B. Nadelman and Others | N Engl J Med 2012;367:1883-1890 Atorvastatin with or without an Antibody to PCSK9 in Primary Hypercholesterolemia E.M. Roth and Others | N Engl J Med 2012;367:1891-1900 | Published Online October 31, 2012 Hydroxyethyl Starch or Saline for Fluid Resuscitation in Intensive Care J.A. Myburgh and Others | N Engl J Med 2012;367:1901-1911 | Published Online October 17, 2012 Trends in Survival after In-Hospital Cardiac Arrest S. Girotra and Others | N Engl J Med 2012;367:1912-1920 Diagnostic Exome Sequencing in Persons with Severe Intellectual Disability J. de Ligt and Others | N Engl J Med 2012;367:1921-1929 | Published Online October 3, 2012 A Phase 3 Trial of RTS,S/AS01 Malaria Vaccine in African Infants The RTS,S Clinical Trials Partnership | November 9, 2012 | DOI: 10.1056/NEJMoa1208394 Variant of TREM2 Associated with the Risk of Alzheimer’s Disease T. Jonsson and Others | November 14, 2012 | DOI: 10.1056/NEJMoa1211103 TREM2 Variants in Alzheimer’s Disease R. Guerreiro and Others | November 14, 2012 | DOI: 10.1056/NEJMoa1211851 Review Article Current Concepts: Accidental Hypothermia D.J.A. Brown, H. Brugger, J. Boyd, and P. Paal | N Engl J Med 2012;367:1930-1938 Images in Clinical Medicine Thoracolumbar Fracture with Preservation of Neurologic Function L.J. Evans | N Engl J Med 2012;367:1939-1939 Hemolytic Anemia after Mitral-Valve Repair S. Puwanant and W. Lohawijarn | N Engl J Med 2012;367:e29 Case Records of the Massachusetts General Hospital Case 35-2012: A 69-Year-Old Chronically Ill Man with Weakness, Anorexia, and Diffuse Pain J.L. Greenwald, S. McDermott, and A.S. Dighe | N Engl J Med 2012;367:1940-1948 Editorials Reinfection versus Relapse in Lyme Disease A.C. Steere | N Engl J Med 2012;367:1950-1951 Diagnostic Exome Sequencing — Are We There Yet? H.C. Mefford | N Engl J Med 2012;367:1951-1953 | Published Online October 3, 2012 Malaria Vaccine Trials — Beyond Efficacy End Points J.P. Daily | November 9, 2012 | DOI: 10.1056/NEJMe1213392 Variant TREM2 as Risk Factor for Alzheimer’s Disease H. Neumann and M.J. Daly | November 14, 2012 | DOI: 10.1056/NEJMe1213157 Clinical Implications of Basic Research Basic Implications of Clinical Observations: From Clinical Observation to Mechanism — Heyde’s Syndrome J. Loscalzo | N Engl J Med 2012;367:1954-1956 Correspondence Thyroid Nodules with Indeterminate Cytology Tofacitinib in Active Ulcerative Colitis Effect of HIV-2 Infection on HIV-1 Disease Progression Patient Access to Medical Devices