Featured Online Highlight Clinical Decisions Preexposure Prophylaxis for HIV Prevention S.S. Abdool Karim, G.E. Gray, and N. Martinson Two patients — a 46-year-old man from New York who has sex with men and an 18-year-old heterosexual woman with multiple partners in South Africa — are at risk for infection with HIV. Would you recommend initiating preexposure prophylaxis? Vote and comment at NEJM.org. This Week at NEJM.org | July 12, 2012 Listen to the Weekly Audio Summary Perspective The Growing Role of Emergency Departments in Hospital Admissions J.D. Schuur and A.K. Venkatesh | July 11, 2012 | DOI: 10.1056/NEJMp1204431 Redefining Physicians’ Role in Assisted Dying J.J.Z. Prokopetz and L.S. Lehmann | N Engl J Med 2012;367:97-99 Cents and Sensitivity — Teaching Physicians to Think about Costs L. Rosenbaum and D. Lamas | N Engl J Med 2012;367:99-101 Finland, Weinstein, and the Birth of Antibiotic Regret K.A. Sepkowitz | N Engl J Med 2012;367:102-103 Zen and the Art of Pediatric Health Maintenance P. Klass | N Engl J Med 2012;367:103-105 Original Articles Improved Survival with MEK Inhibition in BRAF-Mutated Melanoma K.T. Flaherty and Others | N Engl J Med 2012;367:107-114 | Published Online June 4, 2012 Potassium Channel KIR4.1 as an Immune Target in Multiple Sclerosis R. Srivastava and Others | N Engl J Med 2012;367:115-123 Hydroxyethyl Starch 130/0.42 versus Ringer’s Acetate in Severe Sepsis A. Perner and Others | N Engl J Med 2012;367:124-134 | Published Online June 27, 2012 Blockade of Lymphocyte Chemotaxis in Visceral Graft-versus-Host Disease R. Reshef and Others | N Engl J Med 2012;367:135-145 Antiretroviral Prophylaxis for HIV Prevention in Heterosexual Men and Women J.M. Baeten and Others | July 11, 2012 | DOI: 10.1056/NEJMoa1108524 Preexposure Prophylaxis for HIV Infection among African Women L. Van Damme and Others | July 11, 2012 | DOI: 10.1056/NEJMoa1202614 Antiretroviral Preexposure Prophylaxis for Heterosexual HIV Transmission in Botswana M.C. Thigpen and Others | July 11, 2012 | DOI: 10.1056/NEJMoa1110711 Clinical and Biomarker Changes in Dominantly Inherited Alzheimer’s Disease R.J. Bateman and Others | July 11, 2012 | DOI: 10.1056/NEJMoa1202753 Review Article Drug Therapy: Management of Opioid Analgesic Overdose E.W. Boyer | N Engl J Med 2012;367:146-155 Videos in Clinical Medicine Neonatal Circumcision C.K. Cagno and P.R. Gordon | N Engl J Med 2012;367:e3 Images in Clinical Medicine Denervation Atrophy of the Tongue after Hypoglossal-Nerve Injury L. Junquera and L. Gallego | N Engl J Med 2012;367:156-156 Yellow Urticaria B. Narváez-Moreno and J.J. Pereyra-Rodríguez | N Engl J Med 2012;367:e4 Case Records of the Massachusetts General Hospital Case 21-2012: A 27-Year-Old Man with Fatigue, Weakness, Weight Loss, and Decreased Libido D.P. Hunt and Others | N Engl J Med 2012;367:157-169 Editorials Promises from Trametinib in RAF Active Tumors E.A. Sausville | N Engl J Med 2012;367:171-172 | Published Online June 4, 2012 Antibodies to Potassium Channels in Multiple Sclerosis A.H. Cross and E. Waubant | N Engl J Med 2012;367:172-174 Preexposure Prophylaxis for HIV — Where Do We Go from Here? M.S. Cohen and L.R. Baden | July 11, 2012 | DOI: 10.1056/NEJMe1207438 Clinical Decisions Preexposure Prophylaxis for HIV Prevention S.S. Abdool Karim, G.E. Gray, and N. Martinson | July 11, 2012 | DOI: 10.1056/NEJMclde1207706 Clinical Implications of Basic Research Obesity and Pharmacologic Control of the Body Clock S.A. Shea | N Engl J Med 2012;367:175-178 Correspondence Olaparib in Platinum-Sensitive Ovarian Cancer Dengue Glycemic Management of Type 2 Diabetes Mellitus Diabetic Retinopathy Uncomplicated Urinary Tract Infection Correction: Case 12-2012: An Infant with Vomiting Effect of Abuse-Deterrent Formulation of OxyContin Correction Niacin in Patients with Low HDL Cholesterol Levels Receiving Intensive Statin Therapy Image Challenge What is the diagnosis? Submit Answer » Browse All Online First Articles » <><> <><> <><> <><> Trends: Most Viewed (Last Week) A Reader's Guide to 200 Years of the New England Journal of Medicine January 5, 2012 The Dénouement of the Supreme Court's ACA Drama July 2, 2012 Hydroxyethyl Starch 130/0.4 versus Ringer's Acetate in Severe Sepsis June 27, 2012 More Trends New! Watch the NEJM 200th Anniversary Documentary Video Getting Better, a short documentary video, explores three remarkable stories of medical progress that have taken place over the 200-year history of the New England Journal of Medicine. View the film in its entirety, or in segments, now on the NEJM 200th anniversary website. VICE DEAN — PENNSYLVANIA Vice Dean, Educational Affairs. Penn State College of Medicine seeks an innovative leader to set the future vision and direction for medical undergraduate education, graduate medical education, and continuing medical education. The College of Medicine operates under unified leadership with the Penn State Milton S. Hershey Medical Center that is recognized as one of the nation's premier academic health centers, recruiting faculty members who are internationally known for their accomplishments in research, education, and patient care.... Looking for a new practice opportunity? View this job and other listings at NEJM CareerCenter. 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